Today I want to tell you about trimethylglycine or TMG and why I have started using TMG in my nutritional balancing programs. 

TMG is an amino acid and works chemically as a methyl donor. It helps the methyl groups assist in the detoxification of heavy metals and toxic chemicals through the liver. Since most of us have livers that are overtaxed and clogged, TMG is useful in cleaning up the liver, which is the primary reason it is used in this program. I will address this issue later in this article.

TMG consists of three methyl groups that are joined to one molecule of the amino acid glycine. When TMG is eaten in food or taken as a supplement, it releases one of the two methyl groups and leaves a substance called dimethylglycine or DMG along with glycine.  Let’s talk about the benefits DMG and glycine.

Dimethylglycine (DMG) – DMG is used to improve speech and behavior in autism. It also is used for attention deficit-hyperactivity disorder (ADHA) and can improve neurological function and control epilepsy. DMG reduces physical and environmental stress, improves oxygen utilization, enhances liver function, and can optimize athletic performance.

Besides all of these benefits, DMG is used as an anti-inflammatory and for anti-aging effects. DMG can improve the immune response and has been used to treat tumors. It enhances anti-viral and anti-bacterial functions. It is also used for respiratory disorders and allergies as well as chronic fatigue. DMG is helpful in treating alcoholism and drug addictions and can lower blood cholesterol and triglycerides, as well as normalize blood pressure and blood glucose levels.

While DMG can be taken as a supplement, it is too yin and therefore not recommended on my nutritional balancing program. However, when you take TMG it breaks down into DMG and you receive all the benefits without the yin effects.

Glycine – Glycine is very important for the formation of collagen. Collagen is used to repair connective tissue such as tendons, ligaments, cartilage, arteries, veins, and other similar structures. The glycine portion of TMG assists with collagen function and may help with sleep and alertness.

Let’s look at several functions of TMG:

  1. Lowering homeocysteine. Homeocysteine is an amino acid but when it exists in excess it contributes to heart disease and artery disease. Homeocysteine levels are more important to monitor when looking at heart disease than cholesterol. High homeocysteine occur when there is not enough TMG or folic acid available in the body. Since mercury and copper toxicity are seen in almost all clients, TMG donates to the methyl groups that aids in the removing of these harmful metals and therefore lowers homeocysteine levels.
  2. Liver Detoxification. Methyl groups are essential for phase 2 liver detoxification pathways. During this phase of detoxification, the fat soluble and/or insoluble toxins that are difficult for the liver to metabolize and eliminate are joined to a methyl group. This makes the toxin more soluble in water and allows the body to prepare the toxin for elimination. It also neutralizes some of the toxic properties of the toxin, making retracing and healing reactions less intense.
  3. Alleviating depression. TMG increases the body’s natural production of S-adenosyl methionine (SAMe), which is a chemical that can help reduce depression.
  4. Reducing the chance of diabetes. Methyl groups assist in the insulin release and help regulate insulin activity. When the body lack methyl groups, diabetes is far more likely to occur.


I use TMG in conjunction with my hair analysis and nutritional balancing program. Dr. Wilson is still doing research on this subject but he has passed down the following criteria for using TMG within our programs:

  1. Poor eliminator patterns on an initial hair analysis test.
  2. High levels of toxic metals – especially when mercury levels are elevated. Mercury may interfere with methylation even more than other toxic metals.
  3. Four lows pattern on an initial hair analysis test or “stuck in four lows” – this occurs when a lows pattern persists for several tests.
  4. Zinc level above 20% on an initial hair analysis.
  5. Very slow oxidation rate.
  6. Anyone having difficulty on a nutritional balancing program while following the diet and supplement program faithfully. Since TMG assist with the removal of metals AND can neutralize some of the toxic properties of toxins, retracing and healing reactions are often less intense. This is great news for many of my clients who have experienced difficult times while detoxing.
  7. Alleviating depression. Since TMG increases the production of SAMe it can in many cases alleviate depression.


Most people have no side effects from TMG. Currently, with Dr. Wilson’s advice, I have asked all my clients to begin TMG at 500 MG a day – taken each morning. Take only 500 MG and only “pure” TMG that is not mixed with other herbs or minerals. Jarrow and Life extension make TMG in 500 MG tablets. You can purchase it on line at or at your local health food store.

Most people feel better after starting TMG and report better sleep. Even when they aren’t sleeping more, they appear to feel more “rested”. They may also experience a little more energy.

A very few people report feeling fatigue and nauseous when beginning TMG and if so, this usually passes within a few days. This reaction is likely due to the release of some toxic metals. TMG can help release trauma and some people may experience retracing symptoms such as anxiety, fear, depression, anger, and others but these usually pass, and in most cases TMG will reduce retracing symptoms.

Too much TMG can cause diarrhea and nausea and may adversely affect cholesterol levels but this should not occur with the small doses recommended on the nutritional balancing program. Never take more unless I direct you to do so and I will only adjust your TMG dosage after consulting with Dr. Wilson.

Children also need less so contact me if you are working with a child on the program and he has not been given a recommended amount of TMG to take.

As clients stabilize and the oxidation rate becomes more balanced, less TMG should be needed. TMG is found in broccoli, beets and other vegetables. However, most of us do not get enough TMG from food alone. At this time most clients will need TMG for at least a year and repeated hair mineral tests will allow me to determine, along with Dr. Wilson’s assistance, when TMG is no longer needed.

All my current clients should take 500 mg of TMG each morning. Upon further testing the amount may be adjusted. I am working with Dr. Lawrence directly on all my client’s cases and he reviews and approves all my programs before they leave my office. Please consider a hair mineral analysis today. It’s a simple and accurate test that allows me to give you a customized plan for achieving optimal health based. Visit my site to learn more about hair mineral analysis!

References: Wilson, Dr. Lawrence; March 2013